Antibody Drugs with Strong Immune Cell Binding Linked to Allergic Reactions
2026.04.08
Research
Antibody therapies have been used to treat diseases for nearly two decades, but their association with harmful immune reactions, including anaphylaxis, remains unclear. Researchers from Chiba University examined how antibodies interact with Fcγ receptors in tumor-bearing mouse models and found that strong Fcγ receptor binding was associated with higher antidrug antibody levels and anaphylaxis, with tumor-associated myeloid cells implicated in this process. These findings may help guide the development of safer antibody therapies.
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In tumor-bearing mouse models, anti-programmed death-ligand 1 antibodies with stronger Fcγ receptor binding were associated with higher antidrug antibody levels and anaphylaxis, with tumor-associated myeloid cells implicated in the capture of these antibodies.